The Mediator

America: The World’s Mediator?

The Argumentative Mediator

In this paper we introduce a negotiation mediator in a multiagent context. When negotiation fails, a mediator can interact with the parties, find out about their goals, ontologies, and arguments for and against negotiation outcome, and suggest solutions based on previous experience. An algorithmic schema to be instantiated with particular argumentation, semantic alignment and case-base reasonin...

The Peace Mediator Effect

Statistical mechanics has proven to be able to capture the fundamental rules underlying phenomena of social aggregation and opinion dynamics, well studied in disciplines like sociology and psychology. This approach is based on the underlying paradigm that the interesting dynamics of multi-agent systems emerge from the correct definition of few parameters governing the evolution of each individu...

The Mediator complex

What is it? The Mediator complex is an enormous, multi-subunit protein complex that regulates gene expression in eukaryotic cells. It acts as a molecular circuit board that integrates physiological and developmental signals and transmits them to RNA polymerase II (Pol II), the enzyme charged with transcription of all protein-encoding genes. Although initially discovered as a cofactor required f...

Activator-Mediator binding regulates Mediator-cofactor interactions.

The 26-subunit, 1.2 MDa human Mediator complex is essential for expression of perhaps all protein-coding genes. Activator binding triggers major structural shifts within Mediator, suggesting a straightforward means to spatially and temporally regulate Mediator activity. By using mass spectrometry (MudPIT) and other techniques, we have compared the subunit composition of Mediator in three differ...